MEDSCI203_celldeath

 Cell Death

Complete the table below
Death type

Characterisation

Result (Scar or Resolution or Death)

Onchosis

Severe injury, leading to cell swelling, leakage, inflamation

Scar

Necroptosis

Programmed necrotic cell death

Scar

Pyroptosis

Inflamazome mediated necrotic death

Scar

Apoptosis

Cell rounding and cytoplasmic fragmentaion

Resolution (assume not overwhelmed)

Autophagic

Doubble membrane vacuoles form and self-degredation occours

Death

 

 

Oncosis mechanics

Reduced ATP leads to supression of the Na+/K+ exchanger resulting in intracelular buildup of Na+ inside the cell

Glycolysis generates H+ and therefore the pH lowers

This activates the !!q@Death17@@Na+/H+ exchanger@!!q

This activates the !!q@Death17@@Na+/Ca2+ exchanger@!!q

Reduced ATP has also disables the  Ca2+ efflux pump

 

 

 

 

 


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